During which trimester is the risk of miscarriage the highest?

Prepare for the Reproductive Physician Assistant National Certifying Examination (PANCE). Utilize flashcards and multiple choice questions, complete with hints and explanations, to confidently approach your exam.

The first trimester is identified as the period with the highest risk of miscarriage, accounting for approximately 80% of all pregnancy losses that occur in the first 12 weeks. During this time, several critical developments are taking place, including implantation of the fertilized egg and the establishment of placental circulation. These early stages are sensitive to a variety of factors, including chromosomal abnormalities in the embryo, maternal health issues, environmental factors, and hormonal imbalances.

As pregnancy progresses into the second and third trimesters, the risk of miscarriage decreases significantly. In fact, once the pregnancy reaches the second trimester (around 13 weeks), the likelihood of loss diminishes as the fetus becomes more developed and established. Therefore, understanding the dynamics of early pregnancy and the associated risks can help healthcare providers and patients manage expectations and care during this crucial period.

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